Plasma sphingolipids: Potential biomarkers for severe hepatic fibrosis in chronic hepatitis C

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Plasma sphingolipids: potential biomarkers for severe hepatic fibrosis in chronic hepatitis C.

The plasma profile of sphingolipids in hepatic fibrosis patients with chronic hepatitis C (CHC) is rarely considered at present. The association between plasma sphingolipids and severe fibrosis in CHC remains an obscure area of research. The aim of the present study was to assess the plasma profile of sphingolipids and to examine the association between plasma sphingolipids and severe fibrosis ...

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Plasma Sphingolipids as Potential Indicators of Hepatic Necroinflammation in Patients with Chronic Hepatitis C and Normal Alanine Aminotransferase Level

Accurate estimation of hepatic necroinflammation caused by chronic hepatitis C (CHC) is crucial for prediction of prognosis and design of therapeutic strategy, which is particularly true for CHC patients with normal alanine aminotransferase (ALT) level. Recent studies have shown that sphingolipids have a close relationship with hepatitis C virus infection. The present study aimed to identify pl...

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Hepatitis C virus (HCV) infection has been associated with hepatic steatosis. However, the role of hepatic steatosis in the pathogenesis of HCV infection remains controversial. In our study, 425 consecutive HCV-viremic patients with biopsy-proven chronic hepatitis C (male, 264; mean age, 49.0 years) were enrolled. Scoring of hepatic steatosis was based on the method described by Kleiner and on ...

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Thyroid dysfunction (TD) among chronic hepatitis C patients with mild and severe hepatic fibrosis.

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ژورنال

عنوان ژورنال: Molecular Medicine Reports

سال: 2012

ISSN: 1791-2997,1791-3004

DOI: 10.3892/mmr.2015.3361